「欲しい」の先を創造する大同化成工業株式会社
Pharmaceutical excipient for oral preparations POVACOAT® was listed as a Japanese Pharmaceutical Excipient (JPE) in December 2012. In terms of chemical structure, it is a synthetic polymer produced by the copolymerization of partially-saponified polyvinyl alcohol with acrylic acid and methyl methacrylate. POVACOAT offers a dense and strong film structure and is used in film coatings to add oxygen barrier effects and moisture-resistance. It also serves as a high-performance binder that offers high binding strength and reduces problems in tablet manufacturing.
(Listed as a Japanese Pharmaceutical Excipient (JPE) in December 2012.)
| Generic name | PVA copolymer |
|---|---|
| Drug name | Copolymer of polyvinyl alcohol, acrylic acid and methyl methacrylate |
| Drug Master File | Registered |
| Precedent use | 72 mg per day (Administration: oral) |
| Type | F | MP | FL (Under development) |
|---|---|---|---|
| Properties (Appearance) | White to yellowish-white lump or powder | White to yellowish-white powder | Slightly yellow, transparent liquid |
| Specifications | JPE | JPE | To be discussed |
| Viscosity (mPa•s) (For reference) | 5.5 | 5.5 | 5.5 |
| Average molecular weight | Approx. 40,000 | Approx. 40,000 | Approx. 40,000 |
| Average particle diameter | Approx. 1.5 mm | Approx. 125μm |
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| Applications | Film coating, wet granulation binder | Wet granulation binders, solid dispersion substrates | Wet granulation binders for film coatings |
Contact us for our microparticle version of POVACOAT (developed upon request).
